⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26832043 | 0.84 | HDAC8 (0.37) | — | |
| SCHEMBL31742514 | 0.75 | — | — | |
| SCHEMBL5684095 | 0.75 | — | — | |
| SCHEMBL82304 | 0.74 | — | — | |
| SCHEMBL15478295 | 0.73 | — | — | |
| SCHEMBL24942539 | 0.72 | CHEK1 (0.38) | — | |
| SCHEMBL30939702 | 0.72 | — | — | |
| SCHEMBL26060663 | 0.71 | HDAC8 (0.32) | — | |
| SCHEMBL31520440 | 0.71 | UHRF1 (0.41) | — | |
| Ammonia Solution, Strong SCHEMBL27508580 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658662-A1 | MACROCYCLIC AMINOPYRIDINE COMPOUNDS AS EGFR INHIBITORS | Yuhan Corporation (KR) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024177360-A1 | MACROCYCLIC AMINOPYRIDINE COMPOUNDS AS EGFR INHIBITORS | YUHAN CORPORATION (KR) | 2024-08-29 | — | — | WO | disclosed |
| EP-4392415-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS AS EGFR INHIBITORS | Yuhan Corporation (KR) | 2024-07-03 | — | — | EP | disclosed |
| US-11981658-B2 | Substituted aminopyridine compounds as EGFR inhibitors | YUHAN CORPORATION (KR) | 2024-05-14 | — | — | US | disclosed |
| CN-117980297-A | Substituted aminopyridine compounds as EGFR inhibitors | 柳韩洋行 | 2024-05-03 | — | — | CN | disclosed |
| US-20230086884-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS AS EGFR INHIBITORS | YUHAN CORPORATION (KR) | 2023-03-23 | — | — | US | disclosed |
| WO-2023027518-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS AS EGFR INHIBITORS | YUHAN CORPORATION (KR) | 2023-03-02 | — | — | WO | disclosed |
| US-20210221785-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | VERNALIS (R&D) LTD (GB) | 2021-07-22 | — | — | US | disclosed |
| EP-3818054-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2021-05-12 | — | — | EP | disclosed |
| CN-112368276-A | Amino-pyrimidinone derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2021-02-12 | — | — | CN | disclosed |
| WO-2020008013-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2020-01-09 | — | — | WO | disclosed |
| WO-2017024180-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2017-02-09 | — | — | WO | disclosed |
| US-20160318854-A1 | Thioamides and Amides for Controlling Animal Pests | BASF SE (DE) | 2016-11-03 | — | — | US | disclosed |
| US-20160066573-A1 | Malononitrile Compounds for Controlling Animal Pests | BASF SE (DE) | 2016-03-10 | — | — | US | disclosed |
| EP-2328889-B1 | ACETYL PYRROLIDINYL INDOLE DERIVATIVE | MSD KK (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-8592428-B2 | Acetyl pyrrolidinyl indole derivative | MSD K. K. (JP) | 2013-11-26 | — | — | US | disclosed |
| US-20120108817-A1 | ACETYL PYRROLIDINYL INDOLE DERIVATIVE | MSD K.K. | 2012-05-03 | — | — | US | disclosed |
| EP-2328889-A1 | ACETYL PYRROLIDINYL INDOLE DERIVATIVE | Banyu Pharmaceutical Co., Ltd. (JP) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010018800-A1 | ACETYL PYRROLIDINYL INDOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-02-18 | — | — | WO | disclosed |