Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.63 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.63 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pd-0299685 SCHEMBL4382735 | 1.00 | CACNA2D1 (0.63) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL119378 | 1.00 | CACNA2D1 (0.63) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL588075 | 1.00 | CACNA2D1 (0.63) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL3124421 | 1.00 | CACNA2D1 (0.63) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL1923704 | 1.00 | CACNA2D1 (0.63) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL25912 | 1.00 | CACNA2D1 (0.63) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL3123592 | 0.98 | CACNA2D1 (0.61) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL3828529 | 0.98 | CACNA2D1 (0.61) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL4378882 | 0.98 | CACNA2D1 (0.61) | CACNA2D1ADRA1ACACNB3CACNA1CPGR | |
| Pd-0299685 SCHEMBL3828531 | 0.98 | CACNA2D1 (0.61) | CACNA2D1ADRA1ACACNB3CACNA1CPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125021-B1 | COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH 2 LIGANDS AND NSAIDS | RECORDATI IRELAND LTD (IE) | 2011-06-08 | — | — | EP | claimed |
| EP-1192125-B1 | MONO-SUBSTITUTED 3-PROPYL GAMMA-AMINOBUTYRIC ACIDS | WARNER LAMBERT CO (US) | 2008-12-31 | — | — | EP | claimed |
| EP-4506001-A2 | SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2025-02-12 | — | — | EP | disclosed |
| EP-3651752-B1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2024-11-20 | — | — | EP | disclosed |
| EP-4069691-B1 | SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2024-09-18 | — | — | EP | disclosed |
| EP-2240467-B1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | EVOTEC AG (DE) | 2013-03-20 | — | — | EP | disclosed |
| EP-1948615-B1 | Pyrazole derivatives useful for the treatment of gynaecological diseases | PFIZER LTD (GB) | 2011-12-14 | — | — | EP | disclosed |
| EP-2172197-A1 | Octanoic acid derivative to treat fibromyalgia and other pains | Warner-Lambert Company LLC (US) | 2010-04-07 | — | — | EP | disclosed |