⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24080154 | 0.82 | SLC6A2 (0.30) | — | |
| SCHEMBL23558599 | 0.76 | — | — | |
| SCHEMBL16079856 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL23536453 | 0.75 | SLC6A2 (0.30) | — | |
| SCHEMBL18776489 | 0.74 | — | — | |
| SCHEMBL17267161 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL27750866 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL20745761 | 0.72 | — | — | |
| SCHEMBL13923483 | 0.72 | PTGS1 (0.32) | — | |
| SCHEMBL24010086 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143161-A1 | HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS | RIGEL PHARMACEUTICALS, INC. | 2023-05-11 | — | — | US | disclosed |
| US-11578078-B2 | Heterocyclic RIP1 inhibitory compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-20210214347-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-07-15 | — | — | US | disclosed |
| US-20210139494-A1 | HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-05-13 | — | — | US | disclosed |
| US-10975064-B2 | RIP1 inhibitory compounds and methods for making and using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-10273249-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LIMITED (GB) | 2019-04-30 | — | — | US | disclosed |
| US-20180179228-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVE | PULMOCIDE LIMITED (GB) | 2018-06-28 | — | — | US | disclosed |
| US-9732098-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LIMITED (GB) | 2017-08-15 | — | — | US | disclosed |