Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19044 | 1.00 | HDAC1 (0.47) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL19479 | 0.82 | HDAC1 (0.53) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL29955 | 0.73 | HDAC1 (0.63) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL28840 | 0.73 | HDAC1 (0.63) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL28842 | 0.73 | HDAC1 (0.63) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL29956 | 0.73 | HDAC1 (0.63) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL28841 | 0.73 | HDAC1 (0.63) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL2733125 | 0.72 | HDAC1 (0.64) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL20023 | 0.72 | HDAC1 (0.64) | HDAC1KCNH2HDAC6HDAC8HDAC2 | |
| SCHEMBL2732655 | 0.72 | GPBAR1 (0.52) | HDAC1KCNH2HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609078-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES | Novartis AG (CH) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025164-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES | NOVARTIS AG (CH) | 2012-03-01 | — | — | WO | claimed |
| EP-2609078-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES | Novartis AG (CH) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025164-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES | NOVARTIS AG (CH) | 2012-03-01 | — | — | WO | disclosed |