SCHEMBL1924010

SCHEMBL1924010

Nc1nc2cc(CCc3ccccc3)ccc2c2cccnc12.Nc1nc2cc(CO)ccc2c2cc(CCc3ccc(Br)cc3)cnc12

nearest known ligand 0.43

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1058762 0.90 TLR7 (0.47) TLR7
SCHEMBL1062394 0.89 TLR7 (0.48) TLR7
SCHEMBL1008350 0.83 KDM4E (0.45) TLR7
SCHEMBL1008775 0.81 HSP90AA1 (0.40) TLR7
SCHEMBL1010258 0.79 ABCB1 (0.44) TLR7
SCHEMBL18752925 0.77 TLR7 (0.56) TLR7
SCHEMBL1061678 0.77 TLR7 (0.56) TLR7
SCHEMBL1008900 0.77 TLR7 (0.47) TLR7
SCHEMBL1006645 0.77 TLR7 (0.61) TLR7
SCHEMBL1007749 0.76 MAP4K4 (0.40) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2328614-A1 MICROPARTICLES FOR USE IN IMMUNOGENIC COMPOSITIONS Novartis AG (CH) 2011-06-08 EP disclosed
WO-2010017330-A1 MICROPARTICLES FOR USE IN IMMUNOGENIC COMPOSITIONS NOVARTIS AG (CH) 2010-02-11 WO disclosed