Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 20/20 | 0.49 |
| ▸ | GUCY1A2 | P33402 | 20/20 | 0.49 |
| ▸ | GUCY1A1 | Q02108 | 20/20 | 0.49 |
| ▸ | GUCY1B1 | Q02153 | 20/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16906982 | 0.79 | GUCY1B2 (0.51) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL18212213 | 0.77 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL17621371 | 0.76 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL16907042 | 0.75 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL16907052 | 0.72 | GUCY1A1 (0.48) | GUCY1A1GUCY1B1 | |
| SCHEMBL17620418 | 0.72 | GUCY1B2 (0.55) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL19240935 | 0.71 | GUCY1A1 (0.40) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL23434369 | 0.70 | GUCY1B2 (0.52) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL23434499 | 0.70 | GUCY1B2 (0.69) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 | |
| SCHEMBL23434887 | 0.69 | GUCY1B2 (0.55) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136309-A1 | USE OF sGC STIMULATORS FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |