Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.63 |
| ▸ | PRKDC | P78527 | 15/20 | 0.63 |
| ▸ | ABL1 | P00519 | 14/20 | 0.63 |
| ▸ | EGFR | P00533 | 14/20 | 0.63 |
| ▸ | HCK | P08631 | 14/20 | 0.63 |
| ▸ | SRC | P12931 | 14/20 | 0.63 |
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | MTOR | P42345 | 14/20 | 0.63 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.63 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.54 |
| ▸ | BTK | Q06187 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19244743 | 0.94 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL401031 | 0.92 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| Carbamic Acid SCHEMBL19244769 | 0.92 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL401662 | 0.90 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| Carbamic Acid SCHEMBL19244770 | 0.88 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| Carbamic Acid SCHEMBL19244748 | 0.87 | KDR (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| Carbamic Acid SCHEMBL19244757 | 0.86 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL399818 | 0.86 | KDR (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL397089 | 0.85 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL868077 | 0.85 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | claimed |