Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.53 |
| ▸ | PRKDC | P78527 | 4/20 | 0.53 |
| ▸ | HCK | P08631 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 5/20 | 0.48 |
| ▸ | BTK | Q06187 | 8/20 | 0.45 |
| ▸ | BLK | P51451 | 2/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19244741 | 0.92 | EGFR (0.55) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL397530 | 0.90 | IGF1R (0.52) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL398643 | 0.86 | IGF1R (0.49) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| Carbamic Acid SCHEMBL19244731 | 0.85 | EGFR (0.58) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL19244745 | 0.85 | BTK (0.60) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL19244762 | 0.84 | RET (0.49) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL19244743 | 0.83 | PIK3CD (0.58) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL399311 | 0.83 | KDR (0.49) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL399529 | 0.82 | IGF1R (0.60) | EGFRKDRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL399611 | 0.79 | EGFR (0.43) | EGFRKDRPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | claimed |