Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.83 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | BLK | P51451 | 2/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924949 | 0.91 | NTRK1 (0.77) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1924757 | 0.91 | NTRK1 (1.00) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1923893 | 0.89 | NTRK1 (0.74) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1924695 | 0.89 | NTRK1 (0.85) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1924937 | 0.88 | NTRK1 (0.88) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1924415 | 0.87 | NTRK1 (0.86) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1925471 | 0.87 | NTRK1 (0.86) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1924684 | 0.87 | NTRK1 (0.89) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1925208 | 0.87 | NTRK1 (0.89) | NTRK1NTRK2PDGFRBKDRRET | |
| SCHEMBL1924701 | 0.87 | NTRK1 (0.82) | NTRK1NTRK2PDGFRBKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |
| US-7514435-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-04-07 | — | — | US | disclosed |