Sugi Predict

Sugi Predict / Compounds / SCHEMBL19248271

SCHEMBL19248271

SCHEMBL19248271

Cc1nc2cccc(CNC(=O)C3CC3c3ccc(CNC(=O)CC(C)(C)C)c4c(=O)n(C5CCC(=O)NC5=O)c(C)nc34)c2c(=O)n1C1CCC(=O)NC1=O

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 8/20 0.47
▸ DDB1 Q16531 7/20 0.47
▸ TNF P01375 1/20 0.47
▸ IL1B P01584 1/20 0.47
▸ IKZF3 Q9UKT9 1/20 0.47
▸ CSNK1A1 P48729 1/20 0.32
▸ IKZF1 Q13422 1/20 0.32
▸ DGAT2 Q96PD7 6/20 0.32
▸ P2RX7 Q99572 5/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL283467 0.89 CRBN (0.59) CRBNDDB1TNFIL1BIKZF3
SCHEMBL282688 0.80 CRBN (0.62) CRBNDDB1TNFIL1BIKZF3
SCHEMBL286218 0.79 CRBN (0.66) CRBNDDB1TNFIL1BIKZF3
SCHEMBL283958 0.79 CRBN (0.60) CRBNDDB1TNFIL1BIKZF3
SCHEMBL282263 0.78 CRBN (0.64) CRBNDDB1TNFIL1BIKZF3
SCHEMBL284416 0.78 CRBN (0.59) CRBNDDB1TNFIL1BIKZF3
SCHEMBL18946375 0.78 CRBN (0.63) CRBNDDB1TNFIL1BIKZF3
SCHEMBL283344 0.77 CRBN (0.58) CRBNDDB1TNFIL1BIKZF3
SCHEMBL18900413 0.77 CRBN (0.58) CRBNDDB1TNFIL1BIKZF3
SCHEMBL282822 0.77 CRBN (0.58) CRBNDDB1TNFIL1BIKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9732064-B2 5-substituted quinazolinone derivatives and compositions comprising and methods of using the same CELGENE CORPORATION (US) 2017-08-15 — — US disclosed