Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132934 | 0.83 | PTPN5 (0.63) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5131182 | 0.83 | PTPN5 (0.63) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19249951 | 0.82 | PTPN5 (0.56) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL29595705 | 0.82 | PTPN5 (0.56) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5882112 | 0.81 | PTPN5 (0.64) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5126899 | 0.80 | PTPN5 (0.58) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16880021 | 0.79 | PTPN5 (0.60) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5881911 | 0.79 | PTPN5 (0.60) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5881908 | 0.79 | PTPN5 (0.60) | PTPN5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5882131 | 0.77 | PTPN5 (0.64) | PTPN5KDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136871-A9 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136871-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2017-08-17 | — | — | WO | disclosed |