Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.81 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.81 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.81 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.81 |
| ▸ | JAK2 | O60674 | 2/20 | 0.71 |
| ▸ | ABL1 | P00519 | 2/20 | 0.71 |
| ▸ | INSR | P06213 | 2/20 | 0.71 |
| ▸ | LCK | P06239 | 2/20 | 0.71 |
| ▸ | FYN | P06241 | 2/20 | 0.71 |
| ▸ | YES1 | P07947 | 2/20 | 0.71 |
| ▸ | LYN | P07948 | 2/20 | 0.71 |
| ▸ | RET | P07949 | 2/20 | 0.71 |
| ▸ | MET | P08581 | 2/20 | 0.71 |
| ▸ | ROS1 | P08922 | 2/20 | 0.71 |
| ▸ | KIT | P10721 | 2/20 | 0.71 |
| ▸ | SRC | P12931 | 2/20 | 0.71 |
| ▸ | BRAF | P15056 | 2/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.71 |
| ▸ | FLT1 | P17948 | 2/20 | 0.71 |
| ▸ | TYK2 | P29597 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20081814 | 0.91 | FGFR1 (0.81) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL29412748 | 0.90 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL16659467 | 0.90 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30274661 | 0.90 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30070526 | 0.89 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30070306 | 0.89 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL18153616 | 0.89 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL18153614 | 0.89 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16659479 | 0.89 | FGFR4 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL2014816 | 0.88 | FGFR1 (0.83) | FGFR1FGFR4FGFR2FGFR3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730931-B2 | Pyrimidine FGFR4 inhibitors | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-15 | — | — | US | disclosed |