Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24438696 | 0.84 | PREP (0.55) | SMN1; SMN2NPC1RAB9ACTRB1 | |
| SCHEMBL12458051 | 0.77 | PSEN1 (0.49) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL927563 | 0.77 | PSEN1 (0.49) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5517082 | 0.76 | HTR2C (0.64) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5517077 | 0.76 | HTR2C (0.64) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10053573 | 0.76 | HTR2C (0.64) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22537068 | 0.76 | HTR2C (0.53) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1978499 | 0.76 | PSEN1 (0.48) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21193323 | 0.76 | HTR2C (0.53) | HTR2CPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29278490 | 0.76 | HTR2C (0.53) | HTR2CPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |