Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 16/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19251630 | 0.86 | PIK3R1 (0.61) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251423 | 0.84 | PIK3CD (0.50) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251422 | 0.76 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251419 | 0.75 | PIK3R1 (0.77) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251631 | 0.73 | PIK3R1 (0.60) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251475 | 0.72 | PIK3CD (0.61) | PIK3CDPIK3R1HCRTR1HCRTR2 | |
| SCHEMBL19251421 | 0.72 | PIK3CD (0.77) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251480 | 0.69 | PIK3R1 (0.56) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251623 | 0.68 | PIK3R1 (0.62) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL27743834 | 0.68 | PIK3CD (0.44) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133655-A1 | BENZOTHIAZINE AND BENZOTHIADIAZINE COMPOUNDS AND PREPARATION AND USE | 浙江大学 | 2017-08-10 | — | — | WO | disclosed |