Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.56 |
| ▸ | RARA | P10276 | 2/20 | 0.50 |
| ▸ | RARG | P13631 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253584 | 0.97 | RARB (0.56) | RARBRARARARGAKR1C2AKR1C1 | |
| SCHEMBL19253583 | 0.95 | RARB (0.54) | RARBRARARARGAKR1C2AKR1C1 | |
| SCHEMBL19270952 | 0.94 | RARB (0.53) | RARBRARARARGAKR1C2AKR1C1 | |
| SCHEMBL14175164 | 0.89 | RARB (0.64) | RARBRARARARGHTR2AHRH3 | |
| SCHEMBL14175166 | 0.89 | RARB (0.64) | RARBRARARARGHTR2AHRH3 | |
| SCHEMBL14175167 | 0.87 | RARB (0.66) | RARBRARARARGHTR2AHRH3 | |
| SCHEMBL8723123 | 0.86 | RARB (0.59) | RARBRARARARGHSD11B1HTR2A | |
| SCHEMBL10005521 | 0.86 | RARB (0.61) | RARBRARARARGHSD11B1HTR2A | |
| SCHEMBL13310852 | 0.86 | RARB (0.68) | RARBRARARARGHTR2AHRH3 | |
| SCHEMBL9563730 | 0.86 | RARB (0.68) | RARBRARARARGHTR2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10240088-B2 | Substituted polyphenyls | MERCK PATENT GMBH (DE) | 2019-03-26 | — | — | US | disclosed |
| US-20170240812-A1 | SUBSTITUTED POLYPHENYLS | MERCK PATENT GMBH (DE) | 2017-08-24 | — | — | US | disclosed |
| US-20170240812-A1 | SUBSTITUTED POLYPHENYLS | MERCK PATENT GMBH (DE) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170240812-A1 | SUBSTITUTED POLYPHENYLS | PDS5A, XPA, F2 | RARB 3043/4885RARA 2927/4885RARG 3410/4885 |
| US-10240088-B2 | Substituted polyphenyls | PDS5A, XPA, PDS5B | RARB 3046/4885RARA 2896/4885RARG 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.