SCHEMBL19254585

SCHEMBL19254585

CCCCCCCCCCCCNC(=O)c1cccc(-n2c(=O)[nH]c3c(C(N)=O)nc(-c4ccc(OCC)cc4)nc32)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 6/20 0.56
HDAC4 P56524 6/20 0.56
HDAC1 Q13547 6/20 0.56
HDAC7 Q8WUI4 6/20 0.56
HDAC2 Q92769 6/20 0.56
HDAC10 Q969S8 6/20 0.56
HDAC11 Q96DB2 6/20 0.56
HDAC8 Q9BY41 6/20 0.56
HDAC6 Q9UBN7 6/20 0.56
HDAC9 Q9UKV0 6/20 0.56
HDAC5 Q9UQL6 6/20 0.56
CSNK2A1 P68400 7/20 0.56
USP2 O75604 3/20 0.54
TSHR P16473 3/20 0.54
NPSR1 Q6W5P4 2/20 0.54
LMNA P02545 2/20 0.54
MAPT P10636 2/20 0.54
ESR1 P03372 1/20 0.54
TP53 P04637 1/20 0.54
MAPK1 P28482 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19254301 1.00 HDAC3 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19254302 1.00 HDAC3 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19254649 0.97 CSNK2A1 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19207421 0.92 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19207429 0.92 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19207497 0.91 HDAC3 (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19254316 0.91 CSNK2A1 (0.61) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19254303 0.88 CSNK2A1 (0.61) CSNK2A1USP2TSHRNPSR1LMNA
SCHEMBL19254292 0.88 CSNK2A1 (0.67) CSNK2A1USP2TSHRNPSR1LMNA
SCHEMBL19254356 0.86 CSNK2A1 (0.59) CSNK2A1USP2TSHRNPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017136689-A1 PURINE COMPOUNDS POSSESSING ANTICANCER ACTIVITY ACADEMIA SINICA (TW) 2017-08-10 WO disclosed