Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24086608 | 0.81 | PARP1 (0.56) | GSK3BPARP1AKR1B1CREBBPBRPF1 | |
| SCHEMBL19228560 | 0.77 | GSK3B (0.47) | GSK3BPARP1AKR1B1CREBBPCYP1A2 | |
| SCHEMBL19255776 | 0.77 | GSK3B (0.47) | GSK3BPARP1AKR1B1CREBBPCYP1A2 | |
| SCHEMBL19228403 | 0.77 | GSK3B (0.47) | GSK3BPARP1AKR1B1CREBBPCYP1A2 | |
| Hydrochloric Acid SCHEMBL29415878 | 0.75 | GSK3B (0.46) | GSK3BPARP1AKR1B1CREBBPCYP1A2 | |
| Hydrochloric Acid SCHEMBL29415777 | 0.75 | GSK3B (0.46) | GSK3BPARP1AKR1B1CREBBPCYP1A2 | |
| SCHEMBL4800956 | 0.75 | PARP1 (0.65) | PARP1CREBBPBRPF1SMN1; SMN2BRD4 | |
| SCHEMBL1562544 | 0.75 | PARP1 (0.65) | PARP1CREBBPBRPF1SMN1; SMN2BRD4 | |
| SCHEMBL1562440 | 0.75 | PARP1 (0.65) | PARP1CREBBPBRPF1SMN1; SMN2BRD4 | |
| SCHEMBL8903161 | 0.75 | PARP1 (0.65) | PARP1CREBBPBRPF1SMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |