Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 1.00 |
| ▸ | SGK1 | O00141 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.62 |
| ▸ | MARK3 | P27448 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926533 | 0.85 | PLK1 (1.00) | PLK1SGK1PLK4CHEK1MAPK13 | |
| SCHEMBL1925910 | 0.84 | PLK1 (1.00) | PLK1SGK1PLK4CHEK1MAPK13 | |
| SCHEMBL1926222 | 0.82 | PLK1 (1.00) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926393 | 0.82 | PLK1 (1.00) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926114 | 0.82 | PLK1 (1.00) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926534 | 0.82 | PLK1 (1.00) | PLK1SGK1PLK4CHEK1MAPK13 | |
| SCHEMBL1925672 | 0.80 | PLK1 (1.00) | PLK1 | |
| SCHEMBL1925791 | 0.80 | PLK1 (1.00) | PLK1 | |
| SCHEMBL1927901 | 0.79 | PLK1 (1.00) | PLK1 | |
| SCHEMBL1926528 | 0.77 | PLK1 (1.00) | PLK1SGK1PLK4CHEK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | claimed |
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | disclosed |