Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 14/20 | 0.62 |
| ▸ | EGFR | P00533 | 6/20 | 0.62 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28516121 | 1.00 | ITK (0.62) | ITKEGFRBTKKCNH2JAK3 | |
| SCHEMBL19256932 | 0.93 | EGFR (0.69) | ITKEGFRBTKKCNH2JAK3 | |
| SCHEMBL28520057 | 0.92 | ITK (0.61) | ITKEGFRBTKKCNH2 | |
| SCHEMBL19257300 | 0.92 | ITK (0.61) | ITKEGFRBTKKCNH2 | |
| SCHEMBL28512491 | 0.89 | EGFR (0.65) | ITKEGFRBTKKCNH2JAK3 | |
| SCHEMBL19257299 | 0.89 | EGFR (0.65) | ITKEGFRBTKKCNH2JAK3 | |
| SCHEMBL19256934 | 0.87 | RET (0.47) | ITKEGFRBTKKCNH2JAK3 | |
| SCHEMBL19256929 | 0.87 | ITK (0.65) | ITKEGFRBTKKCNH2 | |
| SCHEMBL28517767 | 0.87 | ITK (0.65) | ITKEGFRBTKKCNH2 | |
| SCHEMBL28528769 | 0.87 | ITK (0.65) | ITKEGFRBTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602834-B | Bruton's tyrosine kinase inhibitor | 北京盛诺基医药科技股份有限公司 | 2021-01-08 | — | — | CN | disclosed |
| WO-2017133630-A1 | INHIBITOR OF BRUTON'S TYROSINE KINASE | 北京盛诺基医药科技有限公司 | 2017-08-10 | — | — | WO | disclosed |