Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19209193 | 0.98 | RAD52 (0.45) | RAD52FBP1ALDH1A1LMNATDP1 | |
| Hydrochloric Acid SCHEMBL20586638 | 0.98 | RAD52 (0.45) | RAD52FBP1ALDH1A1LMNATDP1 | |
| SCHEMBL20177203 | 0.85 | KDM4E (0.40) | RAD52FBP1ALDH1A1LMNAKDM4E | |
| SCHEMBL8143963 | 0.85 | EPHX1 (0.44) | SLC6A4PTPRB | |
| SCHEMBL6685124 | 0.85 | EPHX1 (0.44) | SLC6A4PTPRB | |
| SCHEMBL4379883 | 0.85 | EPHX1 (0.44) | SLC6A4PTPRB | |
| Hydrochloric Acid SCHEMBL22691671 | 0.83 | EPHX1 (0.42) | ALDH1A1CYP2C9SLC6A4CYP2C19L3MBTL1 | |
| Hydrochloric Acid SCHEMBL22691669 | 0.83 | EPHX1 (0.42) | ALDH1A1CYP2C9SLC6A4CYP2C19L3MBTL1 | |
| SCHEMBL2808151 | 0.83 | PDPK1 (0.46) | ALDH1A1KDM4ELOXL2SMN1; SMN2CYP19A1 | |
| SCHEMBL9048065 | 0.79 | TAAR1 (0.38) | RAD52ALDH1A1SLC6A4LOXL2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | RAD52 4187/4885FBP1 3045/4885ALDH1A1 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.