Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.59 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.59 |
| ▸ | EHMT2 | Q96KQ7 | 13/20 | 0.58 |
| ▸ | EHMT1 | Q9H9B1 | 6/20 | 0.58 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.56 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260694 | 0.99 | SPIN1 (0.58) | TLR7TLR9EHMT2EHMT1SPIN1 | |
| SCHEMBL19260717 | 0.92 | ACP1 (0.54) | TLR7TLR9EHMT2EHMT1SPIN1 | |
| SCHEMBL19260555 | 0.92 | ACP1 (0.54) | TLR7TLR9EHMT2EHMT1SPIN1 | |
| SCHEMBL19272512 | 0.91 | EGFR (0.58) | — | |
| SCHEMBL19260606 | 0.88 | EHMT2 (0.57) | TLR7TLR9EHMT2EHMT1SPIN1 | |
| SCHEMBL19260759 | 0.88 | EHMT2 (0.57) | TLR7TLR9EHMT2EHMT1SPIN1 | |
| SCHEMBL19260628 | 0.88 | ACP1 (0.55) | TLR7TLR9EHMT2DNMT1ACP1 | |
| SCHEMBL19260827 | 0.88 | ACP1 (0.57) | TLR7TLR9EHMT2DNMT1ACP1 | |
| SCHEMBL19260566 | 0.87 | EHMT2 (0.58) | TLR7TLR9EHMT2EHMT1SPIN1 | |
| SCHEMBL19260746 | 0.87 | EHMT2 (0.58) | TLR7TLR9EHMT2EHMT1SPIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254651-B2 | Histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| US-11254651-B2 | Histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| EP-3416963-B1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-3416963-B1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2021-07-28 | — | — | EP | disclosed |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-02-14 | — | — | US | disclosed |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-02-14 | — | — | US | disclosed |
| EP-3416963-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142947-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | EHMT1, EHMT2, BMI1 | TLR7 4549/4885TLR9 3384/4885EHMT2 2/4885 |
| US-11254651-B2 | Histone methyltransferase inhibitors | EHMT1, EHMT2, BMI1 | TLR7 4549/4885TLR9 3384/4885EHMT2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.