Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.74 |
| ▸ | PLK4 | O00444 | 3/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.60 |
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | PIM1 | P11309 | 3/20 | 0.60 |
| ▸ | FLT1 | P17948 | 3/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.60 |
| ▸ | MARK3 | P27448 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.60 |
| ▸ | GSK3A | P49840 | 3/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.60 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926077 | 0.92 | PLK1 (0.68) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1925876 | 0.85 | PLK1 (1.00) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL4676011 | 0.84 | PLK1 (0.55) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926625 | 0.81 | PLK1 (0.85) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926838 | 0.81 | PLK1 (0.68) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1925831 | 0.80 | PLK1 (0.68) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1927390 | 0.80 | PLK1 (0.70) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926979 | 0.79 | PLK1 (0.65) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1927181 | 0.79 | PLK1 (0.65) | PLK1PLK4CHEK1PDPK1ROCK2 | |
| SCHEMBL1926618 | 0.79 | PLK1 (0.74) | PLK1PLK4CHEK1PDPK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | claimed |
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | disclosed |