Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 19/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 12/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 5/20 | 0.56 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.54 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.54 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20720580 | 0.95 | EHMT2 (0.61) | EHMT2DNMT1HDAC1HDAC6HDAC3 | |
| Formic Acid SCHEMBL19260752 | 0.88 | EHMT2 (0.59) | EHMT2DNMT1NSD2 | |
| Formic Acid SCHEMBL19260633 | 0.88 | EHMT2 (0.63) | EHMT2DNMT1NSD2EHMT1ACP1 | |
| Formic Acid SCHEMBL19260662 | 0.88 | EHMT2 (0.56) | EHMT2DNMT1NSD2EHMT1ACP1 | |
| Formic Acid SCHEMBL19260651 | 0.87 | ACP1 (0.53) | EHMT2DNMT1EHMT1ACP1 | |
| Formic Acid SCHEMBL19260750 | 0.87 | EHMT2 (0.51) | EHMT2DNMT1NSD2EHMT1ACP1 | |
| SCHEMBL20720696 | 0.86 | EHMT2 (0.53) | EHMT2DNMT1HDAC1HDAC6HDAC3 | |
| Formic Acid SCHEMBL19260620 | 0.85 | ACP1 (0.51) | EHMT2DNMT1EHMT1ACP1 | |
| Formic Acid SCHEMBL19260539 | 0.85 | EHMT2 (0.52) | EHMT2DNMT1NSD2EHMT1 | |
| Formic Acid SCHEMBL20720760 | 0.85 | EHMT2 (0.54) | EHMT2DNMT1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254651-B2 | Histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| EP-3416963-B1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2021-07-28 | — | — | EP | disclosed |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-02-14 | — | — | US | disclosed |
| EP-3416963-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142947-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | EHMT1, EHMT2, BMI1 | EHMT2 2/4885DNMT1 32/4885HDAC1 75/4885 |
| US-11254651-B2 | Histone methyltransferase inhibitors | EHMT1, EHMT2, BMI1 | EHMT2 2/4885DNMT1 32/4885HDAC1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.