Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045886 | 0.81 | POLB (0.52) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL9507471 | 0.81 | POLB (0.61) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL1902909 | 0.79 | POLB (0.59) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL21315691 | 0.79 | POLB (0.64) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL1903485 | 0.79 | APOBEC3G (0.59) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL6638095 | 0.79 | POLB (0.59) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL3027067 | 0.77 | HPGD (0.36) | POLBHSD17B10KMT2AL3MBTL1HTT | |
| SCHEMBL2929900 | 0.77 | POLB (0.61) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL3887461 | 0.76 | POLB (0.55) | POLBHSD17B10KMT2AL3MBTL1PTPRC | |
| SCHEMBL14691235 | 0.76 | POLB (0.55) | POLBHSD17B10KMT2AL3MBTL1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322945-A2 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| EP-4284370-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| EP-4110333-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| EP-3880208-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-09-22 | — | — | EP | disclosed |
| EP-3849537-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2021061749-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2021-04-01 | — | — | WO | disclosed |
| EP-3746446-A1 | PRC2 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-12-09 | — | — | EP | disclosed |
| WO-2020167952-A1 | MAT2A INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-08-20 | — | — | WO | disclosed |
| WO-2020101736-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2020055758-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |
| WO-2019152419-A1 | PRC2 INHIBITORS | MIRATI THERAPEUTICS, INC (US) | 2019-08-08 | — | — | WO | disclosed |
| EP-3458445-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017214413-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Chrysalis, Inc. (US) | 2017-12-14 | — | — | WO | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017143011-A1 | HISTONE DEMETHYLASE INHIBITORS | Chrysalis, Inc. (US) | 2017-08-24 | — | — | WO | disclosed |