Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 19/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260982 | 0.91 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL179635 | 0.89 | PIK3CG (0.55) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL179592 | 0.89 | PIK3CG (0.55) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL17243344 | 0.89 | PIK3CG (0.49) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL19260975 | 0.88 | PIK3CG (0.48) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL19260979 | 0.88 | PIK3CG (0.57) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL179633 | 0.86 | PIK3CG (0.48) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL19260978 | 0.86 | PIK3CG (0.46) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL16749833 | 0.84 | PIK3CD (0.67) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL10362254 | 0.84 | PIK3CD (0.67) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738644-B2 | Chemical compounds, compositions and methods for kinase modulation | INFINITY PHARMACEUTICALS, INC. (US) | 2017-08-22 | — | — | US | disclosed |