Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 18/20 | 0.64 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.51 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15205182 | 0.78 | IL2 (1.00) | IL2TNFSTIM1ORAI1 | |
| SCHEMBL1828207 | 0.77 | IL2 (0.63) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL15205531 | 0.77 | IL2 (0.68) | IL2TNFSTIM1ORAI1HTT | |
| SCHEMBL4766353 | 0.76 | IL2 (0.63) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL16471113 | 0.76 | IL2 (0.63) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL4766113 | 0.76 | IL2 (0.65) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL4769509 | 0.76 | IL2 (0.65) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL2728343 | 0.76 | IL2 (1.00) | IL2TNFSTIM1ORAI1HTT | |
| SCHEMBL4770059 | 0.76 | IL2 (0.62) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL16471105 | 0.75 | IL2 (0.61) | IL2TNFSTIM1ORAI1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9737534-B2 | Oxazoline and isoxazoline derivatives as CRAC modulators | LUPIN LIMITED (IN) | 2017-08-22 | — | — | US | disclosed |