Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 19/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416495 | 0.75 | P4HTM (0.54) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL3621496 | 0.69 | P4HTM (0.59) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL3621493 | 0.68 | P4HTM (0.63) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL9621696 | 0.68 | P4HTM (0.57) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL30112058 | 0.67 | P4HTM (0.60) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL18405340 | 0.67 | P4HTM (0.60) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL3632804 | 0.67 | P4HTM (0.53) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL3187466 | 0.66 | P4HTM (0.58) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL3635773 | 0.66 | P4HTM (0.55) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 | |
| SCHEMBL69566 | 0.65 | P4HTM (0.63) | P4HTMKDM4EMAPK1L3MBTL1P4HA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773351-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2017-08-23 | — | — | EP | disclosed |