SCHEMBL19264244

SCHEMBL19264244

COC(=O)N1[C@@]2(C)C=C[C@]1(C)C[C@@](O)(c1ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c1)C2

nearest known ligand 0.60

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13877981 0.89 — —
SCHEMBL3704863 0.89 — —
SCHEMBL23808671 0.86 CSF1R (0.48) CSF1R
SCHEMBL19264737 0.85 CSF1R (0.51) CSF1R
SCHEMBL19264351 0.82 CSF1R (0.48) CSF1R
SCHEMBL14385446 0.82 CSF1R (0.49) CSF1R
SCHEMBL14374882 0.82 CSF1R (0.50) CSF1R
SCHEMBL14374924 0.82 CSF1R (0.54) CSF1R
SCHEMBL14374886 0.82 CSF1R (0.50) CSF1R
SCHEMBL14385189 0.82 CSF1R (0.73) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3208269-A1 INHIBITORS OF C-FMS KINASE Janssen Pharmaceutica N.V. (BE) 2017-08-23 — — EP disclosed
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