Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 5/20 | 0.48 |
| ▸ | IGF1R | P08069 | 11/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | KIF5B | P33176 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400538 | 0.89 | TNK2 (0.47) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL6937533 | 0.89 | TNK2 (0.47) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL19264064 | 0.87 | TNK2 (0.38) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL19264070 | 0.85 | TNK2 (0.63) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL2574212 | 0.85 | TNK2 (0.43) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL12296405 | 0.80 | TNK2 (0.48) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL593129 | 0.79 | RAF1 (0.69) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL15070958 | 0.79 | TNK2 (0.51) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL593128 | 0.79 | RAF1 (0.69) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL402204 | 0.79 | TNK2 (0.37) | TNK2IGF1RCYP3A4MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |