Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 4/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.77 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924006 | 0.87 | NTRK2 (1.00) | NTRK2NTRK1MEN1KMT2AGBA1 | |
| SCHEMBL1924019 | 0.77 | NTRK1 (0.86) | NTRK2NTRK1NPC1RAB9AAURKA | |
| SCHEMBL1926377 | 0.76 | NTRK1 (0.85) | NTRK2NTRK1MEN1KMT2ANPC1 | |
| SCHEMBL1924757 | 0.75 | NTRK1 (1.00) | NTRK2NTRK1MEN1KMT2AAURKA | |
| SCHEMBL12537705 | 0.75 | NTRK2 (0.79) | NTRK2NTRK1MEN1KMT2ANPC1 | |
| SCHEMBL1925131 | 0.74 | NTRK2 (1.00) | NTRK2NTRK1NPC1RAB9AAURKA | |
| SCHEMBL1924486 | 0.74 | NTRK1 (0.91) | NTRK2NTRK1AURKAPLK4DAPK3 | |
| SCHEMBL1925320 | 0.73 | NTRK1 (0.79) | NTRK2NTRK1MEN1KMT2ANPC1 | |
| SCHEMBL1925208 | 0.72 | NTRK1 (0.89) | NTRK2NTRK1NPC1RAB9AAURKA | |
| SCHEMBL1924399 | 0.72 | NTRK1 (0.82) | NTRK2NTRK1NPC1RAB9AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | claimed |