Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19265530 | 0.88 | TLR8 (0.44) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL19265449 | 0.87 | TLR8 (0.41) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL19265633 | 0.87 | TLR8 (0.44) | TLR8HPGDMAPK1HRH3ALDH1A1 | |
| SCHEMBL19265432 | 0.85 | TLR8 (0.40) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL19265529 | 0.84 | TLR8 (0.43) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL19265634 | 0.83 | HPGD (0.41) | TLR8HPGDMAPK1ALDH1A1ABL1 | |
| SCHEMBL10345311 | 0.82 | TLR8 (0.45) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL10344972 | 0.81 | TLR8 (0.45) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL19265537 | 0.79 | TLR8 (0.41) | TLR8HPGDL3MBTL1KDM4EMAPK1 | |
| SCHEMBL19265627 | 0.79 | HPGD (0.36) | TLR8HPGDL3MBTL1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3208263-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | VentiRx Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |