Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Venetoclax. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 known ✓ | P10415 | 20/20 | 0.99 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.99 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.99 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.99 |
| ▸ | NSD2 | O96028 | 1/20 | 0.99 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.99 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.99 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.99 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.99 |
| ▸ | BID | P55957 | 1/20 | 0.99 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.99 |
| ▸ | ASPH | Q12797 | 1/20 | 0.99 |
| ▸ | BAD | Q92934 | 1/20 | 0.99 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.99 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.99 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Venetoclax SCHEMBL523816 | 0.99 | BCL2 (1.00) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| Venetoclax SCHEMBL29801595 | 0.99 | BCL2 (1.00) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| Venetoclax SCHEMBL29360081 | 0.99 | BCL2 (1.00) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| Venetoclax SCHEMBL29390802 | 0.99 | BCL2 (1.00) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| Venetoclax SCHEMBL29353714 | 0.99 | BCL2 (1.00) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| Venetoclax SCHEMBL19278892 | 0.99 | BCL2 (0.98) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| Venetoclax SCHEMBL19278891 | 0.99 | BCL2 (0.98) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| SCHEMBL16038769 | 0.98 | BCL2 (0.96) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| SCHEMBL16038376 | 0.98 | BCL2 (0.96) | BCL2BCL2L1MCL1BCL2L2NSD2 | |
| SCHEMBL1699816 | 0.97 | BCL2 (0.96) | BCL2BCL2L1MCL1BCL2L2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643322-B1 | SALTS AND CRYSTALLINE FORMS OF AN APOPTOSIS-INDUCING AGENT | ABBVIE INC (US) | 2017-08-30 | — | — | EP | claimed |