Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190650 | 0.90 | GCK (0.45) | GCKNOS1AOC3HDAC1HDAC6 | |
| SCHEMBL12305709 | 0.85 | GCK (0.38) | GCKNOS1AOC3HDAC1HDAC6 | |
| SCHEMBL191831 | 0.84 | GCK (0.41) | GCKNOS1AOC3 | |
| SCHEMBL191232 | 0.82 | GCK (0.41) | GCKNOS1AOC3MEN1NPC1 | |
| SCHEMBL191869 | 0.82 | GCK (0.44) | GCKNOS1AOC3MAOBGAA | |
| SCHEMBL192067 | 0.82 | GCK (0.44) | GCKNOS1AOC3HDAC1HDAC6 | |
| SCHEMBL190783 | 0.82 | GCK (0.40) | GCKNOS1AOC3HDAC1HDAC6 | |
| SCHEMBL191596 | 0.81 | GCK (0.44) | GCKNOS1AOC3HDAC1HDAC6 | |
| SCHEMBL192244 | 0.81 | GCK (0.44) | GCKNOS1AOC3HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL191165 | 0.80 | GCK (0.43) | GCKNOS1AOC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |