Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.83 |
| ▸ | BCR | P11274 | 11/20 | 0.83 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.83 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.83 |
| ▸ | KIT | P10721 | 5/20 | 0.83 |
| ▸ | LCK | P06239 | 4/20 | 0.83 |
| ▸ | LYN | P07948 | 4/20 | 0.83 |
| ▸ | FLT3 | P36888 | 4/20 | 0.83 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.83 |
| ▸ | SRC | P12931 | 3/20 | 0.83 |
| ▸ | LDLR | P01130 | 2/20 | 0.83 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.83 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.83 |
| ▸ | CA12 | O43570 | 1/20 | 0.83 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.83 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.83 |
| ▸ | STK10 | O94804 | 1/20 | 0.83 |
| ▸ | CA1 | P00915 | 1/20 | 0.83 |
| ▸ | CA2 | P00918 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944582 | 0.92 | ABL1 (0.85) | ABL1BCRPDGFRBPDGFRAKIT | |
| Hydrochloric Acid SCHEMBL15703833 | 0.92 | ABL1 (0.84) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL29580067 | 0.91 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL7901 | 0.91 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL29366964 | 0.91 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL22930329 | 0.91 | ABL1 (0.89) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL1459790 | 0.90 | ABL1 (0.99) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL1984397 | 0.90 | ABL1 (0.99) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL9990634 | 0.90 | ABL1 (0.99) | ABL1BCRPDGFRBPDGFRAKIT | |
| Nilotinib SCHEMBL31005052 | 0.90 | ABL1 (0.99) | ABL1BCRPDGFRBPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020226201-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SKIN HYPOCHROMATISM, HEALTH FUNCTIONAL FOOD, AND COSMETIC COMPOSITION | 경상대학교병원 | 2020-11-12 | — | — | WO | disclosed |
| EP-2357182-B1 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| EP-2368889-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2011-09-28 | — | — | EP | disclosed |
| US-20110218187-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2011-09-08 | — | — | US | disclosed |
| EP-2357182-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| US-7956053-B2 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2011-06-07 | — | — | US | disclosed |
| US-20090286821-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2009-11-19 | — | — | US | disclosed |
| EP-2100891-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-7569566-B2 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | NOVARTIS AG (CH) | 2009-08-04 | — | — | US | disclosed |
| US-20080188451-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2008-08-07 | — | — | US | disclosed |
| US-20070093506-A1 | Inhibitors of tyrosine kinases | BREITENSTEIN WERNER | 2007-04-26 | — | — | US | disclosed |
| US-7169791-B2 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2007-01-30 | — | — | US | disclosed |
| US-20060167015-A1 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | NOVARTIS AG (CH) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093506-A1 | Inhibitors of tyrosine kinases | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885PDGFRB 358/4885 |
| US-20110218187-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885PDGFRB 358/4885 |
| US-20080188451-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885PDGFRB 358/4885 |
| US-20090286821-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | ABL1 1/4885BCR 28/4885PDGFRB 358/4885 |
| US-20060167015-A1 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | ABL1, CDK2, CDKN1A | ABL1 1/4885BCR 181/4885PDGFRB 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.