Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14973992 | 1.00 | PDE10A (0.72) | PDE10ANR1I2CYP2C9KCNN3 | |
| SCHEMBL14973985 | 1.00 | PDE10A (0.72) | PDE10ANR1I2CYP2C9KCNN3 | |
| SCHEMBL14982005 | 1.00 | PDE10A (0.72) | PDE10ANR1I2CYP2C9KCNN3 | |
| SCHEMBL19281166 | 1.00 | PDE10A (0.72) | PDE10ANR1I2CYP2C9KCNN3 | |
| SCHEMBL19288422 | 0.84 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14973831 | 0.84 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14973595 | 0.84 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14974152 | 0.84 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14973993 | 0.83 | PDE10A (0.59) | PDE10A | |
| SCHEMBL19281167 | 0.83 | PDE10A (0.59) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621926-B1 | PYRAZOLOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-08-30 | — | — | EP | disclosed |