Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901068 | 0.83 | ALK (0.57) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL1493535 | 0.80 | ALK (0.60) | ALKINSRLRRK2 | |
| SCHEMBL11916333 | 0.79 | ALK (0.60) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL11916429 | 0.76 | ALK (0.79) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL11900968 | 0.76 | ALK (0.51) | ALKINSREGFRIGF1RZAP70 | |
| SCHEMBL11916458 | 0.75 | ALK (0.80) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL19288500 | 0.74 | ALK (0.54) | ALKINSRZAP70 | |
| SCHEMBL11900797 | 0.73 | ALK (0.53) | ALKINSR | |
| SCHEMBL1493647 | 0.73 | ALK (0.61) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL16752958 | 0.72 | ALK (1.00) | ALKINSRLRRK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3210609-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2017-08-30 | — | — | EP | disclosed |