Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14387916 | 0.78 | KDM4E (0.42) | RIPK1LMNAKDM4EESR1ESR2 | |
| SCHEMBL28701966 | 0.75 | SLC6A2 (0.45) | RIPK1LMNAESR1ESR2TAAR1 | |
| SCHEMBL28105494 | 0.75 | SLC6A2 (0.45) | RIPK1LMNAESR1ESR2TAAR1 | |
| SCHEMBL19445303 | 0.72 | KDM4E (0.44) | RIPK1LMNAKDM4EESR1ESR2 | |
| SCHEMBL14446922 | 0.69 | KDM4E (0.46) | RIPK1LMNAKDM4EESR1ESR2 | |
| SCHEMBL23222204 | 0.69 | KCNH2 (0.42) | RIPK1KDM4ETAAR1HPGDL3MBTL1 | |
| SCHEMBL9248668 | 0.69 | TSHR (0.33) | TDP1 | |
| SCHEMBL2615503 | 0.69 | ESR1 (0.58) | RIPK1LMNAKDM4EESR1IDO1 | |
| SCHEMBL72988 | 0.69 | ESR1 (0.58) | RIPK1LMNAKDM4EESR1IDO1 | |
| SCHEMBL24143907 | 0.68 | KCNH2 (0.44) | RIPK1KDM4ETAAR1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |