Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRL | P40313 | 12/20 | 0.88 |
| ▸ | TMPRSS11D | O60235 | 5/20 | 0.84 |
| ▸ | PSMB8 | P28062 | 6/20 | 0.64 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.60 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.60 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.60 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.60 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.60 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.60 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.60 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.60 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.60 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.60 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.60 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.60 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.60 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.60 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.60 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.60 |
| ▸ | PSMA8 | Q8TAA3 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14538051 | 1.00 | CTRL (0.88) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL8135866 | 1.00 | CTRL (0.88) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL19341742 | 1.00 | CTRL (0.88) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL19289281 | 0.96 | CTRL (0.87) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL8143396 | 0.96 | CTRL (0.87) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL14538012 | 0.96 | CTRL (0.87) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL8123039 | 0.95 | CTRL (0.90) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL22423754 | 0.95 | CTRL (0.90) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL19289605 | 0.95 | CTRL (0.90) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 | |
| SCHEMBL8135868 | 0.95 | CTRL (0.90) | CTRLTMPRSS11DPSMB8PSMB5PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3021862-B1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2017-08-30 | — | — | EP | disclosed |