Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.41 |
| ▸ | SCNN1A | P37088 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171503 | 0.84 | SCNN1A (0.49) | SCNN1A | |
| SCHEMBL6363491 | 0.84 | SCNN1A (0.49) | SCNN1A | |
| SCHEMBL11149117 | 0.83 | PLAU (0.53) | PLAUSCNN1AALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL917428 | 0.83 | SCNN1A (0.49) | SCNN1A | |
| SCHEMBL12550419 | 0.82 | GRM5 (0.38) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1930596 | 0.81 | PLAU (0.56) | PLAUSCNN1AALDH1A1KDM4EHPGD | |
| Bromide SCHEMBL4789645 | 0.80 | PLAU (0.60) | PLAUSCNN1AALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL4693836 | 0.80 | KDM4E (0.62) | PLAUSCNN1AALDH1A1KDM4EHPGD | |
| SCHEMBL1929320 | 0.79 | SCNN1A (0.53) | PLAUSCNN1AALDH1A1KDM4EHPGD | |
| Bromide SCHEMBL4693426 | 0.79 | PLAU (0.61) | PLAUSCNN1AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956059-B2 | Aliphatic amide and ester pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2011-06-07 | — | — | US | disclosed |