Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16023320 | 0.89 | LRRK2 (0.81) | LRRK2 | |
| SCHEMBL16023349 | 0.86 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16023102 | 0.85 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL17427524 | 0.85 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16023342 | 0.85 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16023318 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16023344 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16023063 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16023314 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16024872 | 0.84 | LRRK2 (1.00) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964222-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2017-08-30 | — | — | EP | disclosed |