Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 3/20 | 0.53 |
| ▸ | PDE2A | O00408 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.49 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 7/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | PDE9A | O76083 | 3/20 | 0.36 |
| ▸ | PDE8A | O60658 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000045 | 0.81 | PDE1B (0.60) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL3087681 | 0.80 | PDE1B (0.55) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL8059876 | 0.80 | PDE1B (0.53) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL26233338 | 0.79 | PDE1B (0.77) | PDE1BPDE2APDE4DPDE4APDE1A | |
| SCHEMBL2120812 | 0.78 | PDE1B (0.50) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL18349195 | 0.78 | PDE1B (0.50) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL17507918 | 0.78 | PDE1B (0.66) | PDE1BPDE2APDE4DPDE4APDE1A | |
| SCHEMBL193969 | 0.77 | PDE1B (0.62) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL8055513 | 0.77 | PDE1B (0.57) | PDE1BPDE2APDE4DPDE4APDE5A | |
| SCHEMBL193592 | 0.76 | PDE1B (0.54) | PDE1BPDE2APDE4DPDE4APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023729-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2016-05-04 | — | — | EP | claimed |
| US-9255099-B2 | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-02-09 | — | — | US | claimed |
| EP-2400970-A1 | PDE 1 INHIBITORS FOR OPHTHALMIC DISORDERS | Intra-Cellular Therapies, Inc. (US) | 2012-01-04 | — | — | EP | claimed |
| WO-2010098839-A1 | PDE 1 INHIBITORS FOR OPHTHALMIC DISORDERS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-09-02 | — | — | WO | claimed |
| US-20100173878-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-07-08 | — | — | US | claimed |
| EP-2023729-A2 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007143705-A2 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2007-12-13 | — | — | WO | claimed |
| EP-2023729-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2016-05-04 | — | — | EP | disclosed |
| US-9255099-B2 | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-20100173878-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100173878-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173878-A1 | ORGANIC COMPOUNDS | PDE3A, PDE7A, PDE3B | PDE1B 17/4885PDE2A 6/4885PDE4D 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.