Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591587 | 0.94 | BACE1 (0.36) | BACE1ALOX5PTGESKAT6AALDH1A1 | |
| SCHEMBL2591589 | 0.94 | BACE1 (0.36) | BACE1ALOX5PTGESKAT6AALDH1A1 | |
| SCHEMBL2591584 | 0.94 | BACE1 (0.36) | BACE1ALOX5PTGESKAT6AALDH1A1 | |
| SCHEMBL17004602 | 0.86 | BACE1 (0.36) | BACE1ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL17004603 | 0.86 | BACE1 (0.36) | BACE1ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL17004601 | 0.86 | BACE1 (0.36) | BACE1ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL17606998 | 0.86 | PTGDR2 (0.36) | BACE1ALDH1A1PTGDR2LMNA | |
| SCHEMBL21433323 | 0.84 | BACE1 (0.45) | BACE1ALDH1A1PTGDR2LMNAMAPK1 | |
| SCHEMBL15991534 | 0.84 | BACE1 (0.45) | BACE1ALDH1A1PTGDR2LMNAMAPK1 | |
| SCHEMBL15994984 | 0.83 | BACE1 (0.35) | BACE1ALDH1A1MAPTKMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868738-B2 | Diazine-fused amidines as BACE inhibitors, compositions, and their use | MERCK SHARP & DOHME CORP. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170247377-A1 | DIAZINE-FUSED AMIDINES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170247377-A1 | DIAZINE-FUSED AMIDINES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247377-A1 | DIAZINE-FUSED AMIDINES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | BACE1, BACE2, APP | BACE1 1/4885ALOX5 3099/4885PTGES 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.