⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238073 | 1.00 | — | — | |
| SCHEMBL4237110 | 1.00 | — | — | |
| SCHEMBL4233578 | 1.00 | — | — | |
| SCHEMBL1929791 | 1.00 | — | — | |
| SCHEMBL4057354 | 1.00 | — | — | |
| SCHEMBL12190336 | 1.00 | — | — | |
| SCHEMBL4237115 | 1.00 | — | — | |
| SCHEMBL4233573 | 1.00 | — | — | |
| SCHEMBL10094913 | 0.88 | — | — | |
| SCHEMBL4051879 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030503-B2 | Process for the preparation of epothilones | KOSAN BIOSCIENCES INCORPORATED (US) | 2011-10-04 | — | — | US | disclosed |
| US-8030503-B2 | Process for the preparation of epothilones | KOSAN BIOSCIENCES INCORPORATED (US) | 2011-10-04 | — | — | US | disclosed |
| US-7955824-B2 | Methods of making epothilones | KOSAN BIOSCIENCES INCORPORATED (US) | 2011-06-07 | — | — | US | disclosed |
| WO-2009112077-A1 | PROCESS FOR THE PREPARATION OF EPOTHILONE PRECURSOR COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | WO | disclosed |
| US-20090076289-A1 | Methods of Making Epothilones | KOSAN BIOSCIENCES INCORPORATED (US) | 2009-03-19 | — | — | US | disclosed |
| US-20080319211-A1 | PROCESS FOR THE PREPARATION OF EPOTHILONES | KOSAN BIOSCIENCES, INC. (US) | 2008-12-25 | — | — | US | disclosed |
| WO-2008141130-A1 | PROCESS FOR THE PREPARATION OF EPOTHILONES | KOSAN BIOSCIENCES, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141234-A2 | METHODS OF MAKING EPOTHILONES | KOSAN BIOSCIENCES INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |