Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412528 | 0.81 | KDM4E (0.43) | NPC1F2PLAUELANEKDM4E | |
| SCHEMBL1930028 | 0.80 | NPSR1 (0.56) | NPC1NPSR1GAAF2PLAU | |
| SCHEMBL936108 | 0.79 | GLA (0.37) | NPC1PKMNPSR1GAAELANE | |
| SCHEMBL17997398 | 0.73 | NPSR1 (0.48) | NPSR1GAAF2PLAUELANE | |
| SCHEMBL1930032 | 0.73 | NPSR1 (0.48) | NPC1NPSR1GAAF2PLAU | |
| SCHEMBL28866449 | 0.72 | TSHR (0.43) | NPSR1ALDH1A1MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL1930473 | 0.72 | NPSR1 (0.46) | NPC1NPSR1GAAF2PLAU | |
| SCHEMBL19207112 | 0.72 | NPSR1 (0.46) | NPC1NPSR1GAAF2PLAU | |
| SCHEMBL1412413 | 0.71 | NPSR1 (0.42) | NPC1NPSR1GAAF2PLAU | |
| SCHEMBL3605755 | 0.71 | NPSR1 (0.42) | NPC1NPSR1GAAF2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258690-B1 | Tricyclic amines as intermediates in the synthesis of fungicidal carboxamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-1539717-B1 | MICROBIOCIDAL (E.G FUNGICIDAL) 1,2,3-TRIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| US-7956194-B2 | Microbiocidal (E.G. fungicidal) 1,2,3-triazole derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| EP-2258690-A1 | Tricyclic amines as intermediates in the synthesis of fungicidal carboxamide derivatives | Syngenta Participations AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| CN-100548992-C | The 1,2,3-triazoles derivative of microbicidel (for example sterilization) | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-14 | — | — | CN | disclosed |
| US-20090216027-A1 | MICROBIOCIDAL (E.G. FUNGICIDAL) 1,2,3-TRIAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-7531559-B2 | Fungicidal 1,2,3 triazole derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-20060154967-A1 | e.g. [2-methyl-5-trifluoromethyl-2H-1,2,3-triazole-4-carboxylic acid methyl ester; fungicide; against the phytopathogenic fungi: Fungi imperfecti (Botrytis, Pyricularia, Helminthosporium), Basidiomycetes (Rhizoctonia, Hemileia), Ascomycetes classes (Venturia, Erysiphe), Oomycetes classes (Phytophthora) | SYNGENTA CROP PROTECTION, INC. | 2006-07-13 | — | — | US | disclosed |
| CN-1678593-A | Microbiocidal (e.g. fungicidal) 1,2,3-triazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2005-10-05 | — | — | CN | disclosed |
| EP-1539717-A2 | MICROBIOCIDAL (E.G FUNGICIDAL) 1,2,3-TRIAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018438-A2 | MICROBIOCIDAL (E.G. FUNGICIDAL) 1,2,3-TRIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154967-A1 | e.g. [2-methyl-5-trifluoromethyl-2H-1,2,3-triazole-4-carboxylic acid methyl ester; fungicide; against the phytopathogenic fungi: Fungi imperfecti (Botrytis, Pyricularia, Helminthosporium), Basidiomycetes (Rhizoctonia, Hemileia), Ascomycetes classes (Venturia, Erysiphe), Oomycetes classes (Phytophthora) | CBR3, PAH, CBR1 | NPC1 1169/4885PKM 3535/4885NPSR1 4575/4885 |
| US-20090216027-A1 | MICROBIOCIDAL (E.G. FUNGICIDAL) 1,2,3-TRIAZOLE DERIVATIVES | CBR3, CCR4, CBR1 | NPC1 869/4885PKM 3144/4885NPSR1 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.