Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 4/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.44 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19153946 | 0.85 | AHR (0.44) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL14494371 | 0.84 | CYP11B1 (0.47) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL25300707 | 0.81 | AHR (0.49) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL15339321 | 0.78 | SMYD3 (0.47) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL8653630 | 0.78 | AHR (0.53) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL24192505 | 0.78 | SMYD3 (0.47) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29435574 | 0.78 | AHR (0.53) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL19300089 | 0.77 | SMYD3 (0.41) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL19300088 | 0.77 | SMYD3 (0.41) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL21826365 | 0.76 | PDE3B (0.47) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355695-A1 | SMYD Inhibitors | Epizyme, Inc. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | Epizyme, Inc. (US) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355695-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | PDE3B 1206/4885PDE3A 907/4885CYP1A2 3400/4885 |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | SMYD3, SMYD2, SMURF2 | PDE3B 633/4885PDE3A 440/4885CYP1A2 4274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.