Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193583 | 0.79 | GRM5 (0.57) | NPC1RAB9AMAPTTSHRPOLB | |
| SCHEMBL19428036 | 0.78 | PTGS1 (0.49) | ALDH1A1MAPK11MAPK14MAPK13RAF1 | |
| SCHEMBL17073562 | 0.73 | MAPK11 (0.51) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL14153227 | 0.68 | TAAR1 (0.42) | MAPK11MAPK14MAPK13RAF1MAPK9 | |
| SCHEMBL14061720 | 0.66 | NPC1 (0.41) | ALDH1A1MAPK11MAPK14MAPK13RAF1 | |
| SCHEMBL15383528 | 0.66 | KDM4E (0.57) | NOTUMDEGS1ALDH1A1PRKDCNPC1 | |
| SCHEMBL31145170 | 0.66 | KDM4E (0.57) | NOTUMDEGS1ALDH1A1PRKDCNPC1 | |
| SCHEMBL16544563 | 0.66 | NOTUM (0.49) | NOTUMDEGS1ALDH1A1NPC1RAB9A | |
| SCHEMBL22581822 | 0.66 | NOTUM (0.49) | NOTUMDEGS1ALDH1A1NPC1RAB9A | |
| SCHEMBL18845580 | 0.66 | ADORA1 (0.46) | RAF1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-B1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2012-01-04 | — | — | EP | disclosed |