Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627271 | 0.82 | SCD (0.45) | SCDCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19308486 | 0.82 | SCD (0.45) | SCDCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19527510 | 0.79 | EPHX2 (0.45) | SCDCYP2D6TTREPHX2RBP4 | |
| SCHEMBL20351811 | 0.79 | SLC6A2 (0.45) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15611503 | 0.79 | SCD (0.45) | SCDCYP2D6EPHX2RBP4CYP3A4 | |
| SCHEMBL20333529 | 0.79 | SLC6A2 (0.45) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15611502 | 0.79 | SCD (0.45) | SCDCYP2D6EPHX2RBP4CYP3A4 | |
| SCHEMBL20351812 | 0.76 | SLC6A4 (0.57) | SCDCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22355169 | 0.76 | SLC6A4 (0.57) | SCDCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6819584 | 0.74 | UTS2R (0.57) | SCDCYP2D6TTRRBP4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751877-B2 | Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |