Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627282 | 1.00 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL21180214 | 0.91 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL11466374 | 0.81 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL11449411 | 0.80 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL9597478 | 0.79 | SLC6A4 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL9597486 | 0.79 | SLC6A4 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL9597472 | 0.79 | SLC6A4 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL20858622 | 0.78 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL11310437 | 0.76 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL15629799 | 0.76 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751877-B2 | Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |