Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3642893 | 0.91 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL1932203 | 0.89 | HDAC1 (0.71) | HDAC1HDAC2 | |
| SCHEMBL3765650 | 0.89 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL3641576 | 0.88 | HDAC1 (0.73) | HDAC1HDAC2 | |
| SCHEMBL3641943 | 0.87 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL3642404 | 0.86 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL3643343 | 0.86 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL3645080 | 0.85 | HDAC1 (0.86) | HDAC1HDAC2 | |
| SCHEMBL3639000 | 0.85 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL3640132 | 0.85 | HDAC1 (1.00) | HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130361-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | GRIMM JONATHAN | 2011-06-02 | — | — | US | claimed |
| EP-2185554-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-05-19 | — | — | EP | claimed |
| WO-2009020589-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-02-12 | — | — | WO | claimed |
| US-20110130361-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | GRIMM JONATHAN | 2011-06-02 | — | — | US | disclosed |
| EP-2185554-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009020589-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130361-A1 | SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC5, HDAC2 | HDAC1 1/4885HDAC2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.