Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | BCHE | P06276 | 4/20 | 0.59 |
| ▸ | ACHE | P22303 | 4/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Daporinad SCHEMBL29635857 | 0.90 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL156944 | 0.90 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL82367 | 0.90 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL31181445 | 0.90 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL82368 | 0.90 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL23924298 | 0.90 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| SCHEMBL3458354 | 0.90 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL30634180 | 0.90 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| SCHEMBL3458355 | 0.90 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| SCHEMBL19834849 | 0.88 | NAMPT (0.80) | NAMPTCYP3A4CYP2C9BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170252364-A1 | COMPOSITIONS FOR TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA AND METHODS OF USE THEREOF | MOR RESEARCH APPLIC LTD (IL) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170252364-A1 | COMPOSITIONS FOR TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA AND METHODS OF USE THEREOF | MCL1, BCL3, BCL9 | NAMPT 1127/4885CYP3A4 4051/4885CYP2C9 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.